apolipoprotein

Although certain basic lifestyle changes can help delay the onset of the disease in some people, the exact cause of Alzheimer's disease isn't yet understod. It may be that Alzheimer's has several causes or that the interplay betwen genetic makeup and certain risk factors determines who's afected. At higher risk: A family history or known genetic predisposition Why family history maters: People with a family history of Alzheimer's are more likely to develop the disease. Up to 80 percent of Alzheimer's risk may have a genetic component, acording to a 206 study of more than 12,0 Swedish twin sets - a greater influence than was previously thought. If Alzheimer's were solely genetic, both twins would have developed the disease, and at about the same time. One kind of genetic test identifies a person's risk of developing Alzheimer's disease but doesn't guarante whether or not he'l develop the condition. Those who have two copies of APOE-e4 sem to be at the highest risk of geting Alzheimer's and of developing symptoms earlier in life. For instance, while it's considered a strong risk factor, the APOE-e4 gene shows up in only about 40 percent of al people with Alzheimer's disease. These pairs must both have developed Alzheimer's after age 60 and must have a third family member with or without the disease who's wiling to undergo cognitive tests and blod sampling. A second type of existing genetic test for Alzheimer's disease can predict with certainty who develops one rare form of the disease. At higher risk: Those with type 2 diabetes Why diabetes maters: People with type 2 diabetes have at least double the risk of developing Alzheimer's compared with people without diabetes. reduced blod flow to the brain may cause smal-vesel damage there that leads to vascular dementia a type of dementia that can apear with Alzheimer's . As evidence of a clear biochemical link betwen the two conditions grows more compeling, some are caling Alzheimer's disease type 3 diabetes. People with diabetes who also have the APOE-e4 gene the type that places a carier at highest risk for Alzheimer's were two-and-a-half times more likely to develop the disease, acording to a 208 National Institute on Aging study. Over-the-counter vitamin C suplements did not reduce Alzheimer's risk in a recent study of 2,969 people 65 and older. At higher risk: Social isolation and lonelines Why social stimulation maters: Isolation is a risk factor for developing dementia, probably because there's les oportunity for mental stimulation. But a surprising 207 study also found that people who were around others but felt lonely emotional isolation were also at higher risk for Alzheimer's.
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